Monday April 11, 2011

Plenaries

West Exhibit Hall A

09:30 -10:45

Presiding:  Feehally, Schuster, Kaplan, Larson

ISN Jean Hamburger Award Presentation
Eberhard Ritz

Lillian Jean Kaplan Awards Presentation
Dr. James Calvet and Dr. Gerd Walz

AMGEN Award Presentation

10:10 – 10:40: Plenary Lecture

ISN AMGEN Award Recipient

13:30 -14:30

Presiding:  Ritz, Pollock

13:35 – 13:50: Plenary Lecture

Renal Antioxidant defense systems
Toshio Miyata

13:55 – 14:25: Plenary Lecture:
Cellular Defense systems in Hypoxia: Mechanisms for Renal Protection
Masayuki Yamamoto

Theme I.   Fluid and electrolytes, tubular transport

Rooms 118-120

Session 1

08:00 – 09:15

Water handling and urinary concentration
Chairs: Daniel Bichet (Canada) and Soren Nielsen (Denmark)

08:00-08:25:  Regulation of AQP2 water channel trafficking
Yumi Noda (Japan)

08:25-08:50:  The role of the AQP1 water channel in peritoneal dialysis
Olivier Devuyst (Belgium)

08:50-09:15:  Aquaretics: A new treatment for hyponatremia
Tomas Berl (USA)

Session 2

14:45 – 16:30

Calcium and Phosphate
Chairs:  Jorge Cannata-Andia (Spain) and M Fukagawa (Japan)

14:50-15:15:  Epithelial phosphate transport(ers)
Victor Sorribas (Spain)

15:15-15:40:  Paracellular transport, claudins, and disorders of renal calcium and magnesium handling  
Dominik Müeller (Germany)

15:40-16:05:  Abnormalities of FGF23 and Klotho in CKD: clinical implications
Myles Wolf (USA)

16:05-16:30:  The Calcium-sensing receptor in control of renal function and calcium homeostasi
Daniela Riccardi (UK)

Session 3

16:45 – 18:30

Late Breaking Science for All Themes
Chairs: Roberto Zatz (Brazil), William Couser (USA)

16:45-18:30: TBA

Theme II. Heredity disorders, development, pregnancy

Rooms 220, 222

Session 1

08:00 – 09:15

Mechanisms and Genetic Networks in Genito-urinary Tract Development
Chairs:  Qais Al-Awqati (USA) and Paul Goodyer (Canada)

08:00-08:25: The role of Wnt signaling in planar cell polarity and kidney tubule morphogenesis
Thomas Carroll (USA)

08:25-08:50: Ferritin and the role of iron traffic in organogenesis
Jonathan Barasch (USA)

08:50-09:15: The role of genetic networks in kidney and urinary tract malformations
Maxime Bouchard (Canada)

Session 2

14:45 – 16:30

Renal cystic diseases: basic signaling mechanisms
Chairs: Marie Trudel (Canada) and Lisa Guay Woodford (USA)

14:50-15:15:  Kaplan Lecture 1:  The Function of Nephrocystins during Renal Development and Cystic Kidney Disease
Gerd Walz (Germany)

15:15-15:40:   A role for Kif3A in nephron number and development
Norman Rosenblum (Canada)

15:40-16:05:  New insights into the mechanosensory function of polycystin
 Rong Li (USA)

16:05-16:30:  Role of mTOR signaling in renal diseases: from genes to treatments
Aristotelis Astrinidis (USA)

Session 3

16:45 – 18:30

Prognostic Markers In Hereditary Renal Cystic Disease
Chairs:  Ron Perrone (USA) and Rong Li (USA)

16:50-17:15:  Kaplan Lecture 2: Polycystic Kidney Disease: A Calcium Signaling Disorder
James Calvet (USA)

17:15-15:40: Genetic Modifiers in PKD
York Pei (Canada)

15:40-18:05: Proteomic analyses in Cystic Kidney Disease
Andreas Kistler (Switzerland)

18:05-18:30:  Metabolomic analyses in cystic diseases 
Robert Weiss (USA)

Theme III. Glomerular Diseases and Infectious Diseases of the Kidney

Room 211-214

Session 1

08:00 – 09:15

Nephrotic Syndrome: New insights
Chairs: Sue Quaggin (Canada) and Abdias Hurtado (Peru)

08:00-08:25: CD80 in the pathogenesis of minimal change disease
Eduardo Garin (USA)

08:25-08:50: Identification of the circulating factor in FSGS
Virginia Savin (USA)

08:50-09:15: Angiopoietin-like 4: Potential Role in Minimal Change Disease?
Sumant Chugh (USA)

Session 2

14:45 – 16:30

Glomerular and Renal Diseases Worldwide
Chairs: Omar Abboud (Sudan) and Chih-Wei Yang (Taiwan)

14:50-15:15: Epidemiology and particular features of glomerular disease in China
Haiyan Wang (China)

15:15-15:40:  Dengue
Emmanuel Burdmann (Brazil)

15:40-16:05  Malaria
Saroj K Mishra (India)
 
16:05-16:30: Bacterial Toxins and Renal Injury
Rashad Barsoum (Egypt)

Session 3

16:45 – 18:30

Glomerular Diseases and Treatments
Chairs: Giuseppe Remuzzi (Italy) and David Harris (Australia)

16:50-17:15:  Rituximab in the Treatment of glomerular diseases: current state of the art
Gerald Appel (USA)

17:20 – 18:30: Top Abstracts

OR38: Hypogammaglobulinaemia and infections following Rituximab therapy for Systemic Vasculitis and Systemic Lupus Erythematosus 
Helena Marco, Rachel B. Jones, Rona M. Smith, Fausta Catapano, David R.W. Jayne

OR39: Long-term effects of cyclosporine in children with idiopathic nephrotic syndrome: A single-centre experience 
Rashad Hassan, Amr El-Husseini, Fathy El-Basuony, Ihab Mahmoud, Hussein Sheashaa, Alaa Sabry, Nohir Taha, Nabil Hassan, Nagy Sayed-Ahmad, Mohamed Sobh.

OR40: Treatment of idiopathic membranous nephropathy with ACTH gel (ACTHAR)
Andrew Bomback, Fernando Fervenza, Daniel Cattran, Valentina Irazabal, Alfonso Eirin, Jai Radhakrishnan, Gerald Appel

OR41: Anti-phospholipase A2 receptor antibody in Chinese membranous nephropathy patients   
Wei-Song Qin, Laurence H. Beck, Jr., David J. Salant, Cai-Hong Zeng, Zhao-Hong Chen, Zhi-Hong Liu.

OR42: Evaluation of role of doxycycline on renal functions in patients of diabetic nephropathy 
Hari Krishan Aggarwal, Deepak Jain, Paulomi Talapatra, Raj Kanwar Yadav

Theme IV. Acute Kidney Injury

West Ballroom D 

Session 1

08:00 – 09:15

AKI in special settings
Chair: Riyad Said (Jordan), Neesh Pannu (Canada)

08:00-08:25: Crush syndrome
Ray Vanholder (Belgium)

08:25-08:50: Cancer and the kidney
Colm Magee (Ireland-USA)

08:50-09:15: Pediatric AKI
Stuart Goldstein  (USA)

Session 2

14:45 – 16:30

Mechanisms of Injury and Repair in AKI
Chairs: Joseph Bonventre (USA) and David Sheikh Hamad (USA)

14:50-15:15:  Microcirculation and mitochondrial dysfunction
Can Ince (Netherlands)

15:15-15:40:  Innate immunity: A new therapeutic target for AKI 
Mark Okusa (USA)

15:40-16:05:  Endogenous antioxidant systems 
Anupam Agarwal (USA)

16:05-16:30:  AKI and midkine
Yukio Yuzawa (Japan)

Session 3

16:45 – 18:30

Improving long term outcomes from AKI: Challenges and Opportunities
Chair: Amit Garg (Canada)

16:50-17:10:  AKI as a Risk Factor for CKD and ESRD
Matt James (Canada)

17:10-18:05: Top Abstracts
 
OR43: Acute-on-chronic renal failure predicted adverse outcome after major operation 
Tao-Min Huang, Vin-Cent Wu, Wen-Je Ko, Kwan-Dun Wu

OR44: Sepsis related acute kidney injury 
Fernando Thom, Elvino Barros, Cssia Morsch, Antonio Balbinotto.

OR45: Immediate post-operative serum creatinne (SCr) predicts risk of subsequent acute kidney injury (AKI) after cardiac surgery 
Brent Galli, Julie Ho, Edward Pascoe, Peter Nickerson, David Rush, Manish Sood, Paul Komenda, Joe Bueti, Martina Reslerova, Claudio Rigatto
 
18:05-18:30:  Staying alive post AKI: strategies and results
Ron Wald (Canada)

Theme V. Chronic Kidney Disease: Pathogenesis, Epidemiology, Prevention, Consequences

West Ballroom B 

Session 1

08:00- 09:15

CKD-Mineral and bone disease (CKD-MBD) – 1
Chairs: Tilman Drueke (France) and Michel Chonchol (Venezuela/USA)

08:00-08:25: Klotho and aging
Makoto Kuro-o (Japan/USA)

08:25-08:50: Vitamin D: More than just calcium homeostasis:
Ravi Thadhani (USA)

08:50-09:15: How to noninvasively assess bone status in CKD
Marie-Hélène Lafage -Proust (France)

Session 2

14:45 – 16:30

CKD: Mechanisms of Progression
Chairs: Fadi Fakhouri, (France) and Allison Eddy (USA)

14:50-15:15:   Network gene analysis
Mathias Kretzler (Germany/USA)

15:15-15:40:  Regulatory Immune Cells
David Harris (Australia)

15:40-16:05:   EMT and Pericytes
Jeremy Duffield (USA)

16:05-16:30:  Basic Mechanisms Underlying Diabetic Nephropathy and CKD
Hirofumi Makino (Japan)

Session 3

16:45 – 18:30

CKD: Pathogenesis and complications
Chairs:  Rezvi Sherriff (Sri Lanka) and TM (Daniel) Chan (Hong Kong)

16:50-17:10:  Inflammation, oxidative stress, and cardiovascular disease
Peter Stenvinkel (Sweden)

17:20-18:05: Top Abstracts

OR48: CANPREDDICT: Canadian study for the prediction of dialysis, death and cardiovascular risk in CKD patients: Results of 1 year follow-up 
A. Levin, C. Rigatto, F. Madore, N. Muirhead, O. Djurdjev, On Behalf of Canadian Investigators

OR47: Proteinuria and progression of kidney function among patients with chronic kidney disease  
Tanvir Turin, Pietro Ravani, Matthew James, Braden Manns, Marcello Tonelli, Rob Quinn, Scott Klarenbach, Brenda Hemmelgarn.

OR46: Association between low birth weight and development of renal disease in early adulthood: An analysis of 54,350 patients using the CKD-EPI 
Badrul Munir Sohel, Chris Cardwell, Dermot OReilly, Gerard Savage, Peter McCarron, Damian Fogarty

18:05-18:30: Lipid abnormalities in CKD 
Nosratola  Vaziri (USA)

Theme VI. Hypertension, Diabetes, and Vascular Disease

West Ballroom C 

Session 1

08:00 – 09:15

Genetics and hypertensive, vascular disease and diabetics
Chairs: Peter Rossing (Denmark) and Anna Kottgen (Canada)

08:00-08:25 Genetics of Chronic Kidney Disease and Hypertension 
Caroline Fox (USA)

08:25-08:50: Genes and pharmacogenetics in vascular disease
Merlin Thomas (Australia)

08:50-09:15: Genes and pharmacogenetics in diabetes
Tadashi Konoshita (Japan)

Session 2
14:45 – 16:30

New Mediators in Hypertension
Chairs: Karen Griffin (USA) and Phil Marsden (Canada)

14:50-15:15:   Cardiotonic Steroids in Hypertension and Renal Injury
Joe Shapiro (USA)

15:15-15:40:   Uric acid, Fructose and the Metabolic syndrome
L G Sanchez Lozada (Mexico)

15:40-16:05:   Renalase
Gary V. Desir (USA)

16:05-16:30:  ISH speaker: Leptin, Obesity and Hypertension
John Hall (USA)

Session 3
16:45 – 18:30

Heart Failure in  CKD

Debate: How best to treat diuretic unresponsive CHF?
Chair: Edward Ross (USA)

16:50-17:10:  With Peritoneal dialysis
John Burkart (USA)

17:15-17:35:  With CVVH
Masaaki Nakayama (Japan)

17:35-18:00:  Rebuttal and Summary

18:00-18:30: Top Abstracts

OR49: Fluid overload management clinical workflow to achieve Normohydration implementation into a large dad-information system  
Peter Wabel, Petr Machek, Tomas Jirka, Sebastian Wieskotten, Alberto Arpini, Marcello Bassi, Claudia Amato.

OR50: Right ventricular diastolic function and right heart failure in dialysis patients could be affected by vascular access 
Luca Di Lullo, Carmela Comegna, Roberto Addesse, Giuseppe Roberto Iannacci, Cristina Galderisi, Annalisa Cecilia, Martina Tomaselli, Maddalena Vitale, Antonio Gorini, Pasquale Polito.

Theme VII. End Stage Renal Disease

West Ballroom A 

Session 1
08:00 – 09:15

Cardionephrology
Chairs: Katherine Tuttle (USA) and Peter Stenvinkel (Sweden)

08:00-08:25: Strategies to prevent sudden cardiac death in dialysis patients
Christoph Wanner (Germany)

08:25-08:50: Progression of cardiac and vascular disease in dialysis patients
Ricardo Correa-Rotter  (Mexico)

08:50-09:15: Daily Dialysis - What have we learned, and where do we go from here?
Rita Suri (Canada)

Session 2
14:45 – 16:30

Peritoneal Dialysis
Chairs: Bengt Lindholm (Sweden) and Xueqing Yu (China)

14:50-15:15: Three pore transport mechanisms and icodextrin
Bengt Rippe (Sweden)

15:15-15:40:  Peritonitis and Immune Response
J Madrenas (Canada)

15:40-16:05:  Pathogenic Mechanisms of Peritoneal Fibrosis
 Hui Yao Lan (China)

16:05-16:30:  Metabolic consequences of Peritoneal Dialysis
Roberto Pecoits-Filho (Brazil)

Session 3
16:45 – 18:30

Debate:  Volume is key to control of blood pressure in dialysis patients
Chairs: Suhail Ahmad (USA) and Rajiv Agarwal (USA)

16:50-17:10: Pro
Tevick Ecder (Turkey)

17:15-17:35: Con
Christopher W. McIntyre (UK)

17:35-18:00: Rebuttal and Summary

18:00-18:30: Top Abstracts

OR51: Change of dialysate sodium concentration and its effect on blood pressure, hospitalization and survival  
O. Sergeyeva, L. Usvyat, P. Kotanko, N.W. Levin, C. Mullon, J.A. Diaz-Buxo

OR52: The fluid status evaluation in Hemodialysis (HD) Patients by means of the natriuretic peptides 
Elena Mancini, Emanuele Mambelli, Antonio Bellasi, Daniela Patrono, Antonio Santoro.

Theme VIII. Transplantation   

Rooms 109-110

Session 1
08:00 – 09:15

Chairs: Bertram Kasiske (USA) and Phil Halloran (Canada)

08:00-08:25: The many faces of chronic allograft dysfunction
Christophe Legendre (Paris, France)

08:25-08:50:  Secrets from the transcriptome: molecular risk factors for chronic allograft dysfunction
Michael Mengel (Canada)

08:50-09:15: Individualized therapeutic approaches
Jose Campistol (Spain)

Session 2
14:45 – 16:30

How to both increase organ availability and decrease organ trafficking?
Chairs: Georgi Abraham (India) and Jagbir Gill (Canada)

14:50-15:40:   Declaration of Istanbul: Overview and Current Initiatives
Mustafa Al-Mousawi (Kuwait) and Francis Delmonico ( USA)

15:40-16:05:   Organ Preservation: Update and Future Prospects
Alkesh Jani (USA)

16:05-16:30:   Approaches used in the Developing World
Syed Adibul Hasan Rizvi (Pakistan)

Session 3
16:45 – 18:30

Living donation
Chairs: David Landsberg (Canada) and Steven Chadban (Australia)

16:50-17:15:  Estimation of GFR pre and post donation
Christophe Mariat (France)

17:15-17:40:  Donors with isolated medical abnormalities: safe to use? 
Stephen Textor (USA)

17:40-18:05:  Options for recipients with incompatible donors
Chris Rudge (UK)

18:05-18:30:  Removing financial disincentives vs providing financial awards for donation
S Klarenbach (Canada)

CNE Theme IX

Rooms 301 and 305

Session 1
08:00 – 09:15

KDIGO Session on AKI
Chairs: Ron Wald (Canada) and Daniela Ponce (Brazil)

08:00-08:25: Prevention
Norbert Lameire  (Belgium)

08:25-08:50: Nondialytic Management
Patrick Murray (Ireland)

08:50-09:15: Optimal Prescription
Alison McLeod (UK)

Session 2
14:45 – 16:30

Challenges in chronic dialysis
Chairs: Philip Li (China) and Jacek Manitius (Poland)

14:50-15:15:  How to manage PD patients with extremes of solute transport status
Simon Davies (UK)

15:15-15:40 :   Peritonitis: management quandaries
Peter Blake (Canada)

15:40-16:05:   Managing challenging cases of hypertension in thrice weekly hemodialysis  patients
Kailash Jindal (Canada)

16:05-16:30:  When should one initiate hemodialysis?
Bruce Cooper (Australia)

Session 3
16:45-18:30

Calcium and Phosphate in ESRD
Chair: Tilman Drueke (France) and Oscar Gutierrez (USA)

16:50-17:15:  Hereditary Disorders in phosphate control
Karl Skorecki (Israel)

17:15-15:40:  Cinacalcet and Vitamin D analogues in management of secondary hyperparathyroidism
Tilman Drueke (France)

15:40-18:05:  Vascular Calcification: Mechanisms and therapeutic strategies
Catherine M Shanahan (UK) 

18:05-18:30:  Fetuin and Cardiovascular mortality? 
Markus Ketteler (Germany)

Interventional Nephrology Session

Rooms: 202-204 and 205-206

Session 3
07:15 – 09:15

Peritoneal Dialysis

7:15 – 7:50: What’s New on PD Catheters and Placement Techniques
Steve Ash (USA)

7:50 – 09:15: Workshop
Steve Ash, Steve Wu, Don Schon, Miguel Riella

Renal Pathology Session

Room: 202-204 and 205-206

14:45 – 18:30

Vascular and Systemic Diseases

14:50-15:20: Thrombotic Microangiopathies
Kerstin Amann (Germany)

15:20-3:55: Diabetic Nephropathy
Charles Alpers (USA)

3:55-16:30: Renal Involvement by Lymphoplasmacytic Disorders
Jolanta Kowalewska (Poland)

16:45 – 18:30

Other Renal Diseases and Quiz

16:50-17:15: Tropical Nephropathies
Wesam Ismail (Egypt)

17:15-17:40: Interstitial Nephritis - Drugs and Infection
Cindy Nast (USA)

17:40-18:25: Renal Pathology Quiz
Issam Francis (Kuwait)

West Room 224

08:30 – 11:30 ISN GO Workshop
William Couser, David Harris, Giuseppe Remuzzi/Norberto Perico, Paul Harden and Sarala Naicker