Saturday April 9, 2011

Plenaries

Session 1

West Exhibit Hall A

09:30 -10:45
Presiding: Rodriguez-Iturbe, Feehally 

09:40 – 10:00: Plenary Lecture:
Personal Perspectives on Hemodialysis and Transplantation
Robin Eady (UK)

10:10- 10:40: Plenary Lecture:
Claude Amiel Lecture: The Future of Renal Transplantation: Tolerance and Xenografts?
David Sachs (USA)

Session 2

13:30-14:30
Presiding:  A Levin, Tonelli, Pecoits-Filho

13:45 – 14:10: Plenary Lecture:
John Dirks Lecture: Renal Disease in Indigenous Populations: Lessons from the Australian Aborigine
Wendy Hoy (Australia)

Top basic science abstract from a developing country

YN01: miR-29 is a key regulator of TGF-[beta]/Smad3-mediated fibrosis
Wei Quin

Top clinical science abstract from a developing country

YN02: Differential peptidome profile of serum or urine and combination in different primary nephrotic syndrome
Lanting Huang

Theme I. Fluid and electrolytes, tubular transport

Rooms 118-120

Session 1
08:00 – 09:15

Update on acid-base
Chairs:  Fiona Karet (UK) and Mitch Halperin (Canada)

08:00-08:25: The handling of bicarbonate by the proximal tubule
Walter Boron (USA)

08:25-08:50: Adaptive mechanisms of renal acid excretion
Carsten Wagner (Switzerland )

08:50-09:15: Rhesus protein in renal ammonia transport
David Weiner (USA)

Session 2
14:45 – 16:30

The kidney and urate/uric acid
Chairs: Yoshikatsu Kanai (Japan) and Gerhard Burckhardt (Germany)

14:50-15:15:  Genome-wide association studies identify novel genes in control of uric acid levels, uric excretion, and gout
 Veronique Vitart (UK)

15:15-15:40:  URAT1 and proximal tubular urate transport 
Hitoshi Endou (Japan)

15:40-16:05:  Uromodulin and hereditary juvenile hyperuricemia
Raj Thakker (UK)

16:05-16:30:  Uric acid stones and metabolic syndrome
Khashayar Sakhaee (USA)

Session 3
16:45 – 18:30

Update on tubular structure-function
Chairs: Joost Hoenderop (Netherland) and Heini Murer  (Switzerland)

16:50-17:15: Novel insights into epithelial solute transport from structural studies
Ernest Wright (USA)

17:15-17:40:  Mechanisms of proximal tubular endocytosis
Eric Christensen (Denmark)

17:40 – 18:05: Top Abstracts

OR02: Loss of differentiated intercalated cells in the absence of AE1 
Robert Quinn, Janet Hux, Matthew Oliver, Peter Austin, Marcello Tonelli, Andreas Laupacis

OR03: PTH decreases claudin-12 expression and increase calcium permeability of a proximal tubular cell culture model 
R. Todd Alexander, Andrew Rasmussen, Jelena Borovac, Wanling Pan, Emmanuelle Cordat

18:05-18:30:  Hereditary renal tubular disorders: Effects on calcium and magnesium homeostasis
Joost Hoendrerop (Netherlands)

Theme II. Heredity disorders, development, pregnancy

Rooms 220, 222

Session 1
08:00 – 09:15

Identifying Genetic Loci in Complex Renal Traits: Recent Progress with Genome-Wide Association studies
Chairs: Lisa-Guay Woodford (USA) and Rulan Parekh (Canada)

08:00-08:15: Introduction to GWAS
Rulan Parekh (Canada)

08:15-08:35: Common genetic variants associated with chronic kidney disease pathogenesis
Anna Kottgen (Canada)

08:35-08:55: Using genome-wide associations to identify genetic susceptibility loci for hypertension in African Americans
Adebowale Adeyemo (USA)

08:55-09:15: Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density
Kari Stefansson (Iceland)

Session 2
14:45 – 16:30

Pregnancy: Proteinuria, the Glomerular Basement Membrane, and Pre-eclampsia
Chairs: Ananth Karumanchi (USA) and Mark Brown (Australia)

14:50-15:15:  Modulation of Nephrin Expression by Podocytes in Pre-Eclampsia
Benedetta Bussolati (Italy)

15:15-15:40:  Inflammatory and oxidative stress in preeclampsia
Carl Hubel (USA)

15:40-16:05:  Role of 2-ME, PLGF and Stox1 Transcription Factor in Preeclampsia
R Kalluri (USA)

16:05-16:30:  Pathological basis for long-term consequences of preeclampsia
Michelle Hladunewich (Canada)

Session 3
16:45 – 18:30

Targeted therapies for renal cystic diseases
Chairs: Arlene Chapman (USA) and Chang- Lin Mei (China)

16:50-17:10:  Novel molecular targeted therapies in ADPKD: Rationale and study design. Rudolph Wuthrich (Switzerland)

17:20 – 18:00: Top Abstracts

OR 04: BICC1 a possible new gene for the renal cysts and diabetes syndrome? 
Rhian Clissold, Emma Edghill, Marcus Mitchell, Sian Ellard, Andrew Hattersley, Coralie Bingham.

OR05: Renal hyperfiltration relationship with renal volume in the early stages of autosomal dominant polycystic kidney disease 
Imed Helal, Berenice Reed, Kim Mc Fann, Xiang-Dong Yan, Robert Schrier.

OR06: Inheritance of the medullary sponge kidney: A systematic analysis of a large cohort   
Antonia Fabris, Antonio Lupo, Pier Manuel Ferraro, Maria Stella Graziani, Giovanni Gambaro

18:05-18:30:  Clinical trial design in ADPKD – novel agents and conventional therapies
Dana Miskulin (USA)

Theme III. Glomerular Diseases and Infectious Diseases of the Kidney

Room 211-214

Session 1
08:00 – 09:15

Genetics of Nephrotic syndrome and glomerulonephritis
Chairs: Karl Tryggvason (Finland) and Pierre Ronco (France)

08:00-08:25: Familial focal and segmental glomerulosclerosis
Michelle Winn (USA)

08:25-08:50: Rare Nephrotic Syndromes associated with mutations in phospholipase C epsilon, WT1 and Fibronectin
Friedhelm Hildebrandt (USA)

08:50-09:15: Apolipoprotein L1 and non-muscle myosin IIA and their roles in FSGS
Jeff Kopp (USA)

Session 2
14:45 – 16:30

Vasculitis & Lupus Nephritis
Chair: Gloria Ashuntantang (Cameroon) and Hirofumi Makino (Japan)

14:50-15:15:  Lupus Nephritis: Lessons from Animal Models
Vicki Kelly (USA)

15:15-15:40: Treatment of lupus nephritis - the new KDIGO recommendations
Brad Rovin (USA)

15:40-16:05: ANCA vasculitis - experimental insights
Peter Heeringa (Netherlands)

16:05 -16:30: Vasculitis treatment – EUVAS trial overview
Vladimir Tesar (Czech)

Session 3
16:45 – 18:30

Glomerular Diseases and Mechanisms
Chairs: Gavin Becker (Australia) and Pierre Ronco (USA)

16:50-17:10:  Amyloidosis and other gammopathies: updates on pathogenesis and treatment
Pierre Ronco (France)

17:20 – 18:00: Top Abstracts

OR07: Disease specific risk of venous thromboembolic events in idiopathic glomerulonephritis 
Sean Barbour, Allen Greenwald, Ognjenka Djurdjev, Adeera Levin, Michelle Hladunewich, Daniel Cattran, Heather Reich

OR08: A case of an accelerated uremic neuropathy (acthar)  
Serpil Muge Deger, Kadriye Altok Reis, Galip Guz, Musa Bali, Yasemin Erten

OR09: Serum uric acid level associates with tubular atrophy and interstitial fibrosis in IgA nephropathy 
Jingjing Zhou, Yuqing Chen, Sufang Shi, Suxia Wang, Hong Zhang, Haiyan Wang

18:05-18:30:  New approaches to light chain nephropathies
CA Hutchison (UK)

Theme IV. Acute Kidney Injury

West Ballroom D

Session 1
08:00 – 09:15

Debate:  Fluid Management in AKI: Fill and Spill or Squeeze and Diurese
Chair: Claudio Ronco (Italy)

08:10-08:35: Fill
Neesh Pannu (Canada)

08:35-09:00: Squeeze
Robert Schrier (USA)

09:00-09:15: Rebuttal and Summary

Session 2
14:45 – 16:30

Epidemiology of AKI around the world
Chairs: Emmanuel Burdmann (Brazil) and Babikir Kaballo (Sudan)

14:50-15:15: Characteristics of AKI in the developing and developed world
Jorge Cerda  (Uruguay/USA)

15:15-15:40:   Infection mediated AKI: Tip of the iceberg?
Vivek Jha (India)

15:40-16:05:  Epidemiology of AKI in Latin America a model for the developing world
Raul Lombardi (Uruguay)

16:05-16:30:  International AKI Registry
Josee Bouchard (Canada)

Session 3
16:45 – 18:30

Late Breaking Studies in AKI and CKD
Chairs: Ravi Mehta (USA) and Prasad Devarajan (USA)

16:50-17:15: Overview of Clinical Trials in AKI: Vladimir Perkovic (Australia)

17:15 – 18:30: Top Abstracts

Late Breaking Abstract TBA
OR10: Christof Westenfelder, John Doty, Benjamin Horne, Brent Muhlestein, David Affleck, Shreekanth Karwande, Gilbert Schorlemmer, Anna Gooch, George Reiss, Florian Toegel, Claudia Lange, Axel Zander

OR11: What determines the gap between prescribed and delivered CRRT dose? 
D.N. Cruz, R. Fumagalli, M. Herrera-Gutierrez, M. Formica, P. Inguaggiato, D. Kindgen-Milles, S. Livigni, M. Marchesi, F. Mariano, A. Marinho, G. Monti, R. Robert, S. Vesconi, C. Ronco.

OR13: Preoperative proteinuria is associated with longterm outcomes after coronary artery bypass grafting surgery 
Tao-Min Huang, Vin-Cent Wu, Wen-Je Ko, Kwan-Dun Wu

Theme V. Chronic Kidney Disease: Pathogenesis, Epidemiology, Prevention, Consequences

West Ballroom B  

Session 1
08:00 – 09:15

CKD and Cardiovascular Disease
Chairs: Robert Walker (New Zealand) and BJ Barrett (Canada) 

08:00-08:25: Renal Progression and Cardiovascular Disease
Michael Shlipak (USA)

08:25-08:50: The SHARP trial
David Wheeler (UK)

08:50-09:15 Preventing progression of calcification in CKD patients
Jürgen Floege (Germany)

Session 2
14:45 – 16:30

Aging Kidney Disease and Unusual Kidney Diseases
Chairs:  Meguid El Nahas (UK) and Raimund Pichler (USA)

14:50-15:15:  Of mice and men:  Aging and the Kidney
Leon Ferder (Puerto Rico)

15:15-15:40:  Balkan Nephropathy and AAN
Arthur P Grollman (USA)

15:40-16:05:  Sugar cane nephropathy
Ricardo Correa-Rotter (Mexico)

16:05-16:30:  Sugar intake as a cause of renal disease
Takahiko Nakagawa (USA)

Session 3
16:45 – 18:30

International Aspects of CKD
Chair:  Hai Yan Wang (China) and Marcello Tonelli (Canada)

16:55-17:20:   The spectrum of AKI, AKD, and CKD: Insights from KDIGO
Andrew Levey (USA)

17:20- 17:45:  The prognosis as it relates to each stage of CKD
Paul de Jong (Netherlands)

17:45-18:10:  Global burden of CKD: Differences throughout the world
Alan Cass (Australia)

18:10-18:30: Top Abstracts
 
OR14: Regional variations in medicare spending and racial disparities in preperation for end-stage renal disease 
Bernadette Thomas, Rudolph Rodriguez, Edward Boyko, Ann OHare

Theme VI. Hypertension, Diabetes, and Vascular Disease

West Ballroom C 

Session 1
08:00 – 09:15

Sodium, Aldosterone, and Blood Pressure
Chair: Ana Cusumano (Argentina) and  M F Ramzy (Egypt)

08:00-08:25: Epidemiology and Public Health Consequences of Sodium Restriction
John Forman (USA)

08:25-08:50 ISH-sponsored Lecture:  Dietary Sodium Restriction and other Dietary Interventions
Norman Campbell (Canada)

08:50-09:15: ISH sponsored lecture: A novel role for the mineralocorticoid receptor in podocyte biology 
Toshiro Fujita  (Japan)

Session 2
14:45 – 16:30

New Insights into Diabetic Nephropathy
Chairs: Fuad Ziyadeh (Lebanon) and Sharma Prabhakar (USA)

14:50-15:15:  ACE inhibitor unresponsiveness and Aldosterone Breakthrough
Robert Toto (USA)

15:15-15:40:  Endothelial Dysfunction: A role in diabetic nephropathy?
Ray Harris (USA)

15:40-16:05:  Adiponectin and NADPH oxidase
Kumar Sharma (USA)

16:05-16:30:  New Biomarkers in Diabetic Nephropathy
Peter Rossing (Denmark)

Session 3
16:45 – 18:30

Debate:  Microalbuminuria: A Target for Treatment? Yes or No
Chair: Hans Henrik Parving

16:50-17:10:  Pro
Dick De Zeeuw

17:15-17:35:  Con
Richard Glassock

17:35-18:00: Rebuttal and Summary 

18:00-18:30: Top Abstracts

OR15: Associations of Albuminuria with physical function decline 
Imran Sajjad, Julie Lin

OR16: Incremental value of estimated glomerular filtration rate and albuminuria as independent and additive predictors of renal outcomes in 27,000 high risk people in ontarget and transcend  
Catherine Clase, Peggy Gao, Sheldon Tobe, Matthew McQueen, Anja Grosshennig, Koon Teo, Salim Yusuf, Johannes Mann.

Theme VII. End Stage Renal Disease

West Ballroom A 

Session 1
08:00 – 09:15

A decade of new peritoneal solutions: Where are we now?
Chairs: Joanne Bargman (Canada) and Bengt Lindholm (Sweden)

08:00-08:25: Low glucose degradation project (GDP) solutions - what have the trials shown us?
CC Szeto (Hong Kong)

08:25-08:50: Novel icodextran strategies
Miguel Perez-Fontan (Spain)

08:50-09:15:  Low sodium solutions: bench to bedside
Simon Davies (UK)

Session 2
14:45 – 16:30

Challenging Issues in Dialysis
Chairs: Nathan Levin (USA) and Guillermo Garcia -Garcia (Mexico)

14:55-15:20:   Management of Heparin induced Thrombocytopenia
H N Magnani (Netherlands)

15:20- 15:45:  Renal Replacement for the indigent and undocumented immigrant
Guillermo Garcia-Garcia (Mexico)

15:45-16:10:  Management of chronic pain and terminal illness in dialysis patients
Sara Davison (Canada)

16:10-16:30: Top Abstracts

OR01: Comparing survival on peritoneal dialysis and hemodialysis in patients starting dialysis effectively as outpatients 
Robert Quinn, Janet Hux, Matthew Oliver, Peter Austin, Marcello Tonelli, Andreas Laupacis.

Session 3
16:45 – 18:30

Clinical Evidence in Dialysis
Chairs: Alfred Cheung (USA) and Peter Kerr (Australia)

16:55-17:20:  Use of clinical evidence in dialysis: Where to go from here?
Jonathan Craig (Australia)

17:20- 17:45:  What BP meds are best in hemodialysis and peritoneal dialysis patients to protect CV risk? 
Herman Haller (Germany)

17:45-18:10:  The case for and against hemodiafiltration for the treatment of ESRD
 Chiu-Ching Huang (Taiwan)

18:10-18:30:  Top Abstracts

OR17: Effect of early initiation of dialysis on cardiac structure and function: results from the initiating dialysis early and late study (the ideal study) 
Gillian Whalley, Thomas Marwick, Rob Doughty, John Collins, Bruce Cooper, Carol Pollock, David Harris

Theme VIII. Transplantation   

Rooms 109-110

Session 1
08:00 – 09:15

Acute Rejection in the New Millennium
Chairs: Titte R Srinivas (USA) and Bruce Kaplan (USA)

08:00-08:25: Why histological presence of acute rejection may not confer longterm consequences 
Peter Heeger (USA)

08:25-08:50:  Towards a biomarker signature for rejection and tolerance
Hans Dieter Volk (Germany)

08:50-09:15: Is Acute Rejection Still a Relevant Surrogate Endpoint?
Bruce Kaplan (USA)

Session 2
14:45 – 16:30

Chair:  Jeremy Chapman (Australia)

14:50-15:15:  Should proteinuria be a target for therapy in transplant patients? 
Greg Knoll (Canada)

Debate: Induction Therapy is Required in All Transplants

15:20-15:40: Pro
Flavio Vincenti (USA)

15:45-16:05:  Con: Induction Therapy is Required in All Transplants
Ed Cole (Canada)

16:05-16:30: Rebuttal and Summary

Session 3
16:45 – 18:30

T regulatory cells and tolerance
Chairs: David Sachs (USA) and Hamid Rabb (USA)

16:55-17:20:  T regs in Transplantation
Anil Chandraker (USA)

17:20-17:45:  Dendritic Cells and Transplanatation
Karl Womer (USA)

17:45-18:30: Top Abstracts

OR18: Characterization of regulatory and effector T cells in renal transplant recipients after induction with thymoglobulin vs. basilixmab: an interim report 
Sacha De Serres,  Bechara Mfarrej, Monica Grafals, Ciara Magee, Nader Najafian

OR19: Various mice stem/progenitor cells differ in ability to induce of mixed chimerism and alloantigen tolerance 
Magdalena Baskiewicz, Maciej Halasa, Violetta Dziedziejko, Boguslaw Machalinski

OR20: Mesenchymal stem cells derived from human amniotic fluid ameliorate renal disease in the rat remnant kidney model 
Rita C. Cavaglieri, Pamella S.T. Oliveira, Marcelo Zugaib, Sergio P. Bydlowski, Irene L. Noronha

CNE Theme IX

Rooms 301 and 305

Session 1
08:00 – 09:15

Geriatrics and Nephrology
Chair: Jim Barton

Debate:  Dialysis in the octogenarian Patient

08:10-08:35:   Pro (“Outcomes in octogenarian are excellent”)
SV Jassal (Canada)

08:35-09:00:   Con (“Dialysis treatment only marginally improves outcomes in octogenarians")
Rachel Carson (Canada)

09:00-09:15: Rebuttal and Summary

Session 2
14:45 – 16:30

Psychonephrology
Chairs: Paul Kimmel (USA) and Gavril Hercz (Canada)

14:50-15:15:   The Past and Future of Psychonephrology
Norman B Levy (USA)

15:15-15:40:   Depression and Anxiety in the Renal Patient
Paul Kimmel (USA)

15:40-16:05:   Balint Programs for Psychological Treatment
Marta Novak (Canada)

16:05-16:30:   Cognitive Status in ESRD; Insights from fMRI
Frank Eitner (Germany)

Session 3
16:45 – 18:30

AKI Syndromes
Chairs: Vuddhidej Ophascharoensuk (Thailand) and Ming Zhao (China)

16:50-17:15:  Tumor Lysis Syndrome
 Ahsan Ejaz (Bangladesh/USA)

17:15-15:40:  Hair dyes and rare causes in Tropical Countries
Babikir Kaballo (Sudan)

15:40-18:05:  Leptospirosis
Irmingarda Gueco (Philipines)

18:05-18:30:  Update on drug nephrotoxicity
Rob Walker (New Zealand)

Interventional Nephrology Session

Rooms: 202-204 and 205-206

Session 1
07:15 – 09:15

Ultrassonography

7:15 – 7:20: Introduction
Miguel Riella (BR)

7:20 – 7:40: Research Opportunities in Interventional Nephrology
Prabir Roy-Chaudhury (USA)

7:40 – 8:15: Basis of Ultrasonography for the Nephrologist
William Charles O’Neil (USA)

8:15-08:20: Questions

08:20 – 09:15: Workshop
Charles O’Neil, Arif Asif, Don Schon, Steve Wu, Miguel Riella, Steve Ash

Renal Pathology Session

Room: 202-204 and 205-206

Session 1
14:45 – 18:30

Glomerular Disease 1
14:50-3:30: Minimal Change Disease and Focal segmental Glomeruloscerosis
Vivette D’Agati (USA)

15:30-15:50: Membranous Glomerulonephritis
Alex Magil (Canada)

15:50-16:30: Lupus Nephritis
Jan Weening (Netherlands)

Session 2
16:45 – 18:30

Glomerular Disease 2

16:50-17:15: IgA Nephropathy
Agnes Fogo (USA)

17:15-17:40: Crescentic Glomerulonephritis
Ingeborg Bajema (Netherlands)

17:40-18:05: Membranoproliferative Glomerulonephritis and Dense Deposit Disease
Patrick Walker (USA)

18:05-18:30: Post-infectious and endocarditis related Glomerulonephritis
Marcello Franco (Brazil)

Social Program

7:00 PM - 11:00 PM

A Night at the Vancouver Aquarium (registration required)

Grouse Mountain: The Peak of Vancouver (registration required)