Sunday, April 10, 2011

Plenaries

West Exhibit Hall B

9:30 - 10:45

Presiding: Rodriguez-Iturbe, Gill, Couser

ISN Alfred Newton Richards Award Presentation
Terry Strom

ISN Shire Bywaters Award Presentation
Ravi Mehta

10:10am – 10:40am: Plenary Lecture:
Donald Seldin Lecture: Membranous Nephropathy: Journey from Rat to Man
David J Salant (USA)

13:30 -14:30
Presiding: Ballermann, Brown

13:35 – 2:05pm: Plenary Lecture:
Preeclampsia: New Insights into the Cause and Treatment
Annatto Karumanchi (USA)

Top clinical abstract from developed country

YN04: Elevated Toll-like receptor 4 expression and signaling in muscle from patients with chronic kidney disease (CKD)
Alice Bonanni 

Top basic abstract from developed country

YN03: Bmp7/Smad/Six2 axis maintains nephron progenitor cells in the developing kidney
Mayumi Tomita

Theme I.   Fluid and electrolytes, tubular transport

Rooms 118-120

Session 1
08:00 – 09:15

Update on Tubular Transport
Chairs Hitoshi Endou (Japan) and Roland Blantz (USA)

08:00-08:25: Epithelial amino acid transport
Stefan Bröer (Australia)

08:25-08:50: Organic and inorganic anion transport by the proximal tubule
Peter Aronson (USA)

08:50-09:15: Organic anion transport in the proximal tubule (except urate)
Gerhard Burckhardt (Germany)

Session 2
14:45 – 16:30

Electrolytes (Emphasis on Sodium and Potassium)
Chairs: Victor Schuster (USA) and Johannes Loffing (Switzerland)

14:50-15:15:  Cellular mechanisms of regulated proximal tubular salt handling
Alicia McDonough (USA)

15:15-15:40:  WNK kinases and tubular salt handling
Juan Pablo Arroyo (Mexico)

15:40-16:05:  Potassium channels in control of renal function
Richard Warth (Germany)

16:05-16:30:  Extrarenal control of salt balance
 Jens Tietze (Germany)

Session 3
16:45 – 18:30

The Glomerular Filter
Chair Ton Rabelink (Netherlands) and Dontscho Kerjaschki (Austria)

16:55-17:20:  The glomerular filter and albumin filtration
Wayne Comper (Australia)

17:20- 17:45:  Controlled filtration across the glomerular barrier
 Marcus J Moeller (Germany)

17:45-18:10:  Proteinuria and the role of the endothelial glycocalyx
Ton Rabelink (Netherlands)

18:10 – 18:30: Top Abstracts

OR21: GLEPP1 reduces nephrin endocytosis 
Eva Koenigshausen, Sarah Grabowski, Laura Gerbaulet, Ivo Quack, Magdalena Woznowski, Sebastian A. Potthoff, L. Christian Rump, Lorenz Sellin

Theme II. Heredity disorders, development, pregnancy

Rooms 220, 222

Session 1
08:00 – 09:15

Renal Cystic Diseases: New Insights into Clinical Disease Expression
Chairs: Vince Torres (USA) and Olivier Devuyst (Belgium)

08:00-08:25: Pleiotropic phenotypes result from mutations in the transcription factor, HNF1? 
Coralee Bingham (UK)

08:25-08:50: Subtleties and surprises: the clinical manifestations of autosomal recessive polycystic kidney disease 
Meral Gunay-Aygun (USA)

08:50-09:15:  Clinical studies in ADPKD children: evidence for a critical window of cyst formation and growth
Melissa Cadnapaphornchai (USA)

Session 2
14:45 – 16:30

Genomic mechanisms in kidney development and disease
Chairs: Motoko Yanagita (Japan) and Mario Marco Pontoglio (France)

14:50-15:15: MicroRNAs and the kidney: coming of age 
Scott Harvey (France/Canada)

15:15-15:40:  The specification and maintenance of renal cell types by epigenetic factors
Gregory Dressler (USA)

15:40-16:05: The GUDMAP: a resource for dissecting genitourinary tract development 
Melissa Little (Australia)

16:05-16:30:  Stem cells: the key to renal regeneration?
Giuseppe Remuzzi (Italy)

Session 3
16:45 – 18:00

Hereditary Diseases
Chair: David Warnock (USA)

Debate: Does Treatment of Fabry Disease Matter?
               
16:50-17:10:  Pro 
Stephen Waldek (UK)

17:15-17:35:  Con
Braden Manns (Canada)

17:35-18:00:  Rebuttal and Summary

18:00-18:30: Top Abstracts

OR23: Globotriasylceramide (GB3)- Induced endothelial-to-mesenchymal transition as a novel mechanism of vascular damage in fabry disease 
Mina Yu, Yahg-Hee Jang, Mi-Jin Kim, Eun-Sun Ryu, Hak-Sun Choi, Jin-Ok Choi, Sung-Cheol Jung, Duk-Hee Kang

OR24: Association of eGFR-related loci identified by genone-wide association analysis (GWAS) with incident CKD and ESRD  
Carsten A. Bger, Man Li, Mathias Gorski, Qiong Yang, Murielle Bochud, Abbas Dehghan, Michael M. Hoffmann, Chunmei Huang, Florian Kronenberg, Rainer Rettig, David Siscovick, Ravi Thadhani, Iris M. Heid, Caroline S. Fox, W.H. Linda Kao

Theme III. Glomerular Diseases and Infectious Diseases of the Kidney

Room 211-214

Session 1
08:00 – 09:15

Glomerular Damage and Regeneration: New Insights
Chairs: Andrey Cybulsky (Canada) and Sergio Mezzano (Chile)

08:00-08:25: GBM Proteins and glomerular tuft pathology
Jeff Miner (USA)

08:25-08:50: Parietal cells come of age
Stuart Shankland (USA)

08:50-09:15: Podocyte Polarity Signaling in Health and Disease
Tobias Huber (Germany)

Session 2
14:45 – 16:30

Cellular Mechanisms Influencing GN
Chair: Richard Kitching (Australia) and Rolf Stahl (Germany)

14:50-15:15:  Podocyte Mediator Systems
Peter Mundel (USA)

15:15-15:40:  ER stress and GN
Reiko Inagi (Japan)

15:40-16:05:  Antiinflammatory systems (adenosine and the new cholinergic anti-inflammatory system
Gabriela Garcia  (USA)

16:05-16:30:  Nephrin and Nck
Nina Jones (Canada)

Session 3
16:45 – 18:30

Recent Clinical Breakthroughs and Trials (for all Themes)
Chairs: Nestor Schor (Brazil) and Francesco Locatelli (Italy)

16:50-17:15:  New Breakthroughs:  Role of Soluble Urokinase Receptor (UPAR) in Focal Segmental Glomerulosclerosis
Jochen Reiser (USA)

17:15-17:40: Competing Risks of ESRD and Death in Patients with Diabetes and CKD – Results from TREAT
Robert Toto (USA)

17:40-17:45: Recent Clinical Trials

17:45 – 18:30: TBA

Theme IV. Acute Kidney Injury

West Ballroom D

Session 1
08:00 – 09:15

Breaking Research in AKI
Chairs: Martha Franco (Mexico) and Jonathan Barasch (USA)

08:00-08:25: Genomic tools to characterize AKI
Bertrand Jaber (India-USA)

08:25-08:50: Kidney lung interactions
Sarah Faubel (USA)

08:50-09:15: Real time GFR measurements: are we there yet?
Bruce Molitoris (USA)

Session 2
14:45 – 16:30

Innovations in RRT
Chairs: Tarek El Baz (Egypt) and Victor Gura (USA)

14:50-15:15:  Bywater’s Lecture: Timely interventions with dialysis: a personalized approach
Ravi Mehta (USA)

15:15-15:40:   Miniaturized devices for acute dialysis
Claudio Ronco (Italy)

15:40-16:05:  Cytopheretic filters
David Humes (USA)

16:05-16:30: Low cost alternatives for RRT in the developing world.
Daniela Ponce (Brazil)

Session 3
16:45 – 18:30

Biomarkers in AKI
Chairs: Norbert Lameire (Belgium) and Charles Edelstein (USA)

16:55-17:10:   Biomarkers in renal medicine: improving care or impeding progress
Peter Stenvinkel (Sweden)

17:10-17:35:  Biomarker development and validation for AKI
Prasad Devarajan (USA)

17:35-18:00:  Can we distinguish real injury from functional change? 
Patrick Murray (Ireland)

18:00-18:30: Top Abstracts

OR25: Evaluation of new urinary AKI biomarkers in an adult heterogeneous ICU population  
Kent Doi, Kousuke Negishi, Tomoko Ishii, Daisuke Katagiri, Toshiro Fujita, Takehiro Matsubara, Naoki Yahagi, Takeshi Sugaya, Eisei Noiri.

OR26: Elevated uric acid increases the risk for acute kidney injury, hospital stay and duration of mechanical ventilation in cardiac surgery  
Vijay Lapsia, Richard J. Johnson, Bhagwan Dass, Ganesh Kambhampati, Noel I. Ejaz, Amir A. Arif, A. Ahsan Ejaz

Theme V. Chronic Kidney Disease: Pathogenesis, Epidemiology, Prevention, Consequences

West Ballroom B  

Session 1
08:00 – 09:15

Detection of CKD: International Perspectives
Chair: Dick De Zeeuw (Netherlands) and Saraladevi Naicker (South Africa)

08:00-08:25: Interpretation and use of eGFR in clinical practice
Ayub Akbari (Pakistan-Canada)

08:25-08:50: New Biomarkers in CKD
Chirag Parikh (USA)

08:50-09:15: Regional variations in GFR
Seiichi Matsuo (Japan)

Session 2
14:45 – 16:30

Anemia and EPO
Chairs: Patrick Parfrey (Canada) and Chris Winearls (UK)

14:50-15:15:  Towards better understanding of the risk benefit relationship of ESA - secondary analysis of TREAT
Patrick Parfrey (Canada)

15:15-15:40:  New insights into the pathophysiology and renal anemia and its correction.
Kai-Uwe Eckardt (Germany)

15:40-16:05:  Potential role of ESAs in cancer
Mark Segal (USA)

16:05-16:30:  Quality of life with anemia correction
Robert Foley (Ireland-USA)

Session 3
16:45 – 18:30

Treatment and Prevention of CKD
Chairs: Andrzej Wieczek (Poland) and Paul Stevens (UK)

16:50-17:10:  What is the optimal therapy?
Johannes Mann (Germany)

17:10-18:05: Top Abstracts

OR27: Periodontal disease: A treatable cause for disproportionate edema in chronic kidney disease 
Rajaratnam Krishnan, Vivek Narayan

OR28 : A simple screening strategy to identify rapid renal decline in the general population 
William F. Clark, Jennifer J. Macnab, Jessica M. Sontrop, Arsh K. Jain, Louise Moist, Rita Suri, Amit X. Garg
 
OR29: Associations of dietary fish intake with albumnuria and kidney function decline in women 
Molly McGovern, Gary Curhan, Julie Lin

18:05-18:30:  Models of Healthcare Delivery: Prevention Clinics
Brenda Hemmelgarn (Canada)

Theme VI. Hypertension, Diabetes, and Vascular Disease

West Ballroom C  

Session 1
08:00 – 09:15

Recent Clinical Trials
Chairs: Matt Weir (USA) and Marius Miglinas (Lithuania)

08:00-08:25: ISH-sponsored Lecture Renal Implications in Hypertensive Clinical Trials
Matt Weir (USA)

08:25-08:50: Optimal AntihypertensiveTreatment : The ACCORD Trial
William Cushman (USA)

08:50-09:15: Clinical trials on the management of renal artery stenosis
Keith Wheatley (UK)

Session 2
14:45 – 16:30

Pathogenesis of Primary Hypertension
Chairs: Laszlo Rosivall (Hungary) and Jesus Egido (Spain)

14:50-15:15:  Vasculature, Inflammation and Hypertension
Christopher Wilcox (USA)

15:15-15:40:  Innate immunity and inflammasome  activation
MF McDermott, (UK)

15:40-16:05: The Role of T cells
Bernardo Rodriguez Iturbe (Venezuela)

16:05-16:30:  Endothelial dysfunction and Hypertension
Chris Baylis (USA)

Session 3
16:45 – 18:30

KDIGO Update Hypertension
Chairs: David Wheeler (UK) and Gavin Becker (Australia)

16:50-17:15:  KDIGO Guidelines on Management of Blood Pressure in Non-Diabetic People
Mark Sarnak (USA)

17:25-17:45:  KDIGO Guidelines on Management of Blood Pressure in People with Diabetes
Charlie Tomson (UK)

17:55-18:30:  Top Abstracts

OR30 : What does it actually cost to improve population blood pressure control?   
Christopher Farmer, Jean Irving, Kushan Karunaratne, Helen Hobbs, Richard Kingston,1 Paul Stevens.

OR32 : Albuminuria Response to Angiotensin Receptor Blockade is a Determinant of Renal Protection in Patients with Type 2 Diabetes and Microalbuminuria in the IRMA-2 Trial 
Hiddo J. Lambers Heerspink, Frederik Persson, Peter Rossing, Dick de Zeeuw, Hans-Henrik Parving.

OR31: Patterns of Systolic Blood Pressure are an Important Predictor of Patient Outcomes in Incident Hemodialysis Patients 
Len Usvyat, Stephan Thijssen, Jochen Raimann, E. Lars Penne, Peter Kotanko, Nathan W. Levin

Theme VII. End Stage Renal Disease

West Ballroom A 

Session 1
08:00 – 09:15

Debate: Thrice weekly hemodialysis is obsolete and should no longer be offered as standard treatment for ESRD
Chair: Gary Eknoyan (USA)

08:10-08:35:  PRO
Robert Lindsay (Canada)

08:35-09:00:  CON
Norbert Lameire (Belgium)

09:00-09:15: Rebuttal and Summary

Session 2
14:45 – 16:30

Health Disparities in Dialysis Patients
Chairs: Karen Yeates (Canada) and Guillermo Garcia -Garcia (Mexico)

14:55-15:20:   A methodological approach to reducing disparities
Neil Powe (USA)

15:20- 15:45:  PD in developing countries
S Naga (Egypt)

15:45-16:10:  HD in developing countries
V Jha (India)

16:10-16:30:  Top Abstracts

OR21: Racial and ethnic differences in the association of body mass index and survival in maintenance hemodialysis patients 
Joni Ricks, Miklos Z. Molnar, Csaba P. Kovesdy, Joel D. Kopple, Mahesh Krishnan, Keith C. Norris, Onyebuchi A. Arah, Sander Greenland, Kamyar Kalantar-Zadeh

Session 3
16:45 – 18:30

Quotidian Hemodialysis
Chairs:  Robert Lindsay (Canada) and Jolanta Karpinski (Canada)

16:50-17:10:  Quotidian Dialysis: The Frequent Hemodialysis Network Trials
 Alan Kliger (USA)

17:20-18:00: Top Abstracts

OR33: Daily Hemodialysis and patient survival: A Multi-national cohort study 
Rita S. Suri, Robert Lindsay, Bieber Brian, Pisoni Ronald, Amit Garg, Peter Austin, Louise Moist, Bruce Robinson, Brenda Gillespie, Yun Li, Cecile Couchoud, Eduardo Lacson, Deborah Zimmerman, Roula Galland, Gihad Nesrallah

OR34: Effects of Thrice-weekly In-Center Nocturnal Versus Conventional Hemodialysis on Integrated Backscatter of Myocardial Tissue 
Xiucai Jin, Shu Rong, Chang-Lin Mei, Chaoyang Ye, Jiabin Chen, Xiaoyu Chen.

OR35: Long Hemodialysis and Patient Survival: A Multinational Cohort Study  
Gihad Nesrallah, Robert Lindsay, Meaghan S. Cuerden, Amit Garg, Friedrich Port, Peter C. Austin, Louise M. Moist, Andreas Pierratos, Christopher T. Chan, Deborah Zimmerman, Robert S. Lockridge, Cecile Couchoud, Charles Chazot, Norma Ofsthun, Adeera Levin, Michael Copland, Mark Courtney, Andrew Steele, Phil McFarlane, Denis F. Geary, Robert P. Pauly, Paul Komenda, Rita S. Suri, The International Quotidian Dialysis Registry Investigators.

18:05-18:30:  How can the use of quotidian hemodialysis be increased?
Robert P Pauly (Canada)

Theme VIII. Transplantation   

Rooms 109-110

Session 1
08:00 – 09:15

Issues facing women in transplantation 
Chairs: Milagros Samaniego (Philippines/USA) and Diane McKay (Canada)

08:00-08:25: Counseling the transplant patient after successful pregnancy
Diane McKay (USA)

08:25-08:50:  Ethical Quandaries in Transplant (i.e. dyspaternity)
Aviva Goldberg (Canada)

08:50-09:15: CVD progression in adolescent and pediatric pre and post transplant: with emphasis on gender
Bethany Foster (Canada)

Session 2
14:45 – 16:30

Complications post transplant
Chairs: John Gill (Canada) and Venkat Ramanathan (USA)

14:50-15:15:   Cardiovascular disease
Helen Pilmore (New Zealand)

15:15-15:40:   Cancer Screening
Bryce Kiberd (Canada)

15:40-16:05:   Vaccinations
CN Kotton (USA)

16:05-16:30:   Immunosuppression adjustment in diabetic subjects
Steven Chadban (Australia)

Session 3

16:45- 18:30

Transplant Outcomes

Debate: Chronic Allograft Dysfunction: What is the primary cause? 
Chair: Bruce Kaplan (USA)

16:50-17:10:  Immune mediated due to antibody
Phil Halloran (Canada)

17:15-17:35:  Calcineurin Toxicity:  Chronic allograft dysfunction
Jeremy Chapman (Australia)

17:35-18:00:  Rebuttal and Summary

18:00-18:30:  Top Abstracts

OR36: The Impact of Dialysis Exposure on Transplant Outcomes Differs in Canada and the United States  
Caren Rose, Edward Cole, Peter Nickerson, Greg Knoll, John Gill

OR37: Outcomes of Cadaveric Expanded Criteria Donors in Kidney Transplantation   
Julie Lin, Anil Chandraker

CNE Theme IX

Rooms 301 and 305

Session 1
08:00 – 09:15

Fluid and Electrolytes: Case Studies
Chair: Kamel Kamel (Canada) and Jeremy Levy (UK)

08:00-08:25: Renal tubular acidosis
Mitch Halperin (Canada)

08:25-08:50: Diabetes Insipidus
Daniel Bichet (Canada)

08:50-09:15: Regulation of Calcium and Phosphate
Bryan Kestenbaum (USA)

Session 2
14:45 – 16:30

Glomerulonephritis
Chairs: Sarala Naicker (South Africa) and Ming Zhao (China)

14:50-15:15:   Membranous Nephropathy: Update on Treatment
Daniel Cattran (Canada)

15:15-15:40:   Treatment of Lupus Nephritis
David Jayne (UK)

15:15-15:40:   HIV nephropathy:  Impact in Africa and Current Status
Sarala Naicker (South Africa)

16:05-16:30:   Tacrolimus as a primary treatment for nephrotic syndrome
Xuequing Yu (China)

Session 3
16:45 – 18:30

Challenging Issues in Transplant
Chairs: Flavio Vincenti (USA) and Kim Muczynski (USA)

16:50-17:15 : BK virus
Michelle A. Josephson (USA)

17:15-17:40: Glomerular diseases following Bone Marrow and Renal Transplantation
Paolo Mene (Italy)

17:40-18:05:  Post transplant Lymphoproliferative Disorder
Dan Brennan (USA)

18:05-18:30: Evolution of deceased donor transplantation in India with decline of commercial transplantation -a lesson for developing countries
Georgi Abraham (India)

Interventional Nephrology Session

Rooms: 202-204 and 205-206

Session 2
07:15 – 09:15

Vascular Access

07:15 – 07:40: What the Nephrologist Should Know About Vascular Access
Arif Asif (USA)

07:40 – 07:45: Questions

07:45 – 09:15: Workshop
Arif Asif, Don Schon, Steve Ash, Steve Wu, Miguel Riella

Renal Pathology Session

Room: 202-204 and 205-206

14:45 – 16:30

Glomerular and Tubulointerstitial Disease

14:50-15:20: Hereditary Nephropathies
Agnes Fogo (USA)

15:20-15:50: Differential Diagnosis of chronic tubulointerstitial injury
Dusan Ferluga (Slovenia)

15:50-16:10: Crystalline Nephropathies
Glen Markowitz (USA)

16:10-16:30: Case Presentations
Masaomi Nangaku (Japan)

16:50 – 18:30

Transplantation

16:50-17:20: Differential Diagnosis of Inflammation in Transplant Biopsies
Michael Mengel (Canada)

17:20-17:50: Establishing the Diagnosis of Antibody Mediated Rejection
Mark Haas (USA)

17:50-18:10: Chronic Allograft Injury – Challenges in Diagnosis
Mark Haas (USA)

18:10-18:30: Case Presentations.
Venkat Ramanathan (USA)